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List of Courses
* All credit hours are based on the current term, this may vary for previous terms.
| HONC320 - Mechanisms of Malig,Hemat &Onc |
(7 credit hours) |
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| INFE310 - Infection,Inflammation &Immun |
(7 credit hours) |
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| MCRO123 - Principles of Micro. &Immun |
(3 credit hours) |
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All |
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| MMIM603 - Molecular Principles of Viral |
(2 credit hours) |
Molecular Prinicples of Viral Replication and Pahtogenesis:
Virology has made a significant contribution in revolutionizing modern molecular biology. Many of the tools of molecular biology in use today were conceived of while studying viruses, their replication and ability to cause disease. Thus, this course will focus on virus replication and pathogenesis. Understanding the basic steps of virus replication is important for combating virus spread since these steps can serve as targets for intervention. Similarly, a study of viral pathogenesis is critical for not only successful control of virus transmission, but also towards the development of vaccines and other novel therapeutic agents. Hence, the first part of the course will introduce basic principles that unite all viruses and will discuss the molecular basis of virus replication and pathogenesis. In addition, it will also cover effects of viruses on the host cell since the life cycle of viruses are intricately connected to the host cell functions. This will include topics related to the ability of viruses to persist into the host cell, cause latency, acquire cellular genes (viral oncoproteins), as well as the ability to transform host cells. The second part of the course will present an in-depth view of major viral groups that cause human diseases, including retroviruses, adeno- and adeno-associated viruses, papillomaviruses, herpesviruses, influenza, and hepatitis viruses. The focus of these lectures, once again, will be on the specifics of virus replication and pathogenesis within the specific viral group.
The format of the course will be lectures and active participation of the students is a must. The class will meet once a week for approximately two hours with a fifteen minutes break.
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Spring |
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| MMIM604 - Mol.&Cell.Bas.of Parasit. Inf. |
(2 credit hours) |
Molecular and Cellular Basis of Parasitic Infections:
This course is designed to introduce students to both traditional parasitology and more recent developments in molecular and imaging technologies. Diseases caused by parasitic infections have shown considerable evolution over the last few decades. Major parasitic infections and diseases used to be gastrointestinal parasites such as amoebae, roundworms, hookworms, tapeworms, flukes and malaria. With the improvement of socioeconomic and hygienic conditions, many of these diseases have disappeared from the developed countries while new problems have emerged, such as drug resistance and increased transmission due to induced and acquired immunosuppression. Examples of such infections are malaria, strongyloidiasis, giardiasis and leishmaniasis. Methods of diagnosis too have been revolutionized. In the past, microscopic examination of blood, feces and urine was the mainstream of parasitology. Today, these have been largely replaced by DNA based methods and imaging technologies such as ultrasound, CT and MRI.
Approximately half the course will be on conventional parasitology, systematic, microscopy etc. The other half will deal with molecular mechanisms of disease, molecular methods of diagnosis, application of imaging technologies, role of immunosuppression in the transmission of disease, vaccine development and molecular mechanisms of drug resistance.
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Fall Spring |
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| MMIM605 - Gene Therapy |
(1 credit hours) |
Gene therapy is the novel, state-of-the-art approach to treating human disorders using nucleic acids as the therapeutic agent. The disorders open to gene therapy include inherited genetic deficiencies, infectious and autoimmune maladies and extends to chronic and acquired diseases such as diabetes, cancer, and cardiovascular diseases. Thus, gene therapy aims to cure medical problems at the source; illnesses that otherwise were incurable, did not have effective treatments, or treatments that affected only the symptoms, but not the cause.
This course will provide the student with a comprehensive overview of the field of gene therapy from the basics to the ethical implications. It will cover topics related to the fundamentals of gene delivery, how it can be used as a new form of therapy, what are some of the gene delivery systems (both viral and non-viral), what strategies have been used for therapy within the organism, what are some of the successes and failures in human, and finally what are some of the ethical and legal considerations that arise out of this new field of medicine. The goal of the course is to familiarize the student with the basics of gene therapy and bring them up-to-date as to where gene therapy stands today both technologically and ethically.
The format of the course will be Seminars and student directed presentations.
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Fall |
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| MMIM607 - Antibiotics&Antimicrobial Res. |
(1 credit hours) |
This course covers the pharmacological, microbiological and laboratory aspects of anti-bacterial agents, anti-infective therapy and antibiotic resistance.
The core knowledge to understand the various approaches to anti-infective therapy, to conduct and interpret anti-microbial sensitivity testing and to understand the bases of laboratory monitoring of drug therapy will be provided.
Anti-bacterial drugs, their chemistry, mode of action and pharmacological properties will be described while special emphasis will be put on the molecular bases, genetics, mechanisms and importance of anti-microbial resistance.
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Fall Spring |
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| MMIM608 - Immune mediated diseases |
(2 credit hours) |
From the topics covered in a prerequisite course of cellular and molecular basis of immune reactivity it is clear that a fully functional immune system is necessary for survival and health. It also appears that there is an obvious and dangerous potential for the immune system to kill its host. This course discusses the consequences of differentiational arrests in the development and different types of pathogenic immune reactivity that cause immune mediated diseases.
This Course will cover at an advanced level, cellular and molecular mechanisms underlying inappropriate immune responses leading to tissue damage. The first part includes pathological immune response to self-antigens. The course will also cover the mechanisms of loss of tolerance to self, the failure of the regulatory mechanism of immune responses and pathogenic role of different effector cells and molecules leading to progression of diseases in experimental models and human pathology. Particular emphasis will be given to the immunodiagnostic modalities and disease monitoring. The second includes the responses characterized as hypersensitivity reactions caused by a response to innocuous antigen (allergy) or an exaggerated response to an infectious agent. The third part of the course is to discuss primary immune deficiency diseases.
This course will also cover therapeutic aspects of immune-mediated diseases including anti-inflammatory agents, cytokines and cytokine antagonists and inhibitors, immunotherapy of allergy, and new approaches including stem cell and gene therapy in autoimmunity.
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Spring |
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| MMIM610 - Elective on Vaccines |
(1 credit hours) |
This is a 1 CH Elective designed to provide a broad understanding of vaccines, immunology and molecular biology of vaccine development and recent developments. Special emphasis will be on the failure of vaccine development during the last 3-4 decades, primarily in HIV, Malaria and Tuberculosis as opposed to relatively successful vaccines for influenza and bacterial infections. The advantages and limitation(s) of recombinant and molecular biological approaches to develop molecularly defined vaccines will be discussed. More than 50% of the content delivery will be by students in the form of discussions and classroom presentations.
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Fall Spring |
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